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Q Exactive

Q Exactive

The Thermo Scientific Q Exactive hybrid quadrupole-Orbitrap mass spectrometer combines high-performance quadrupole precursor selection with high-resolution, accurate-mass (HR/AM) Orbitrap™ detection. The superior quality of Q Exactive™ MS/MS data provides ultimate confidence for a wide range of qualitative and quantitative applications. Its high scan speed and spectral multiplexing capabilities make it fully compatible with UHPLC and fast chromatography techniques, ramping productivity to a new level.

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  • Descripción

    The Q Exactive instrument can easily handle routine applications in proteomics from bottom-up protein ID to semiquantitative isotopic labeling analyses to targeted quantification experiments. At the same time, its innovative HR/AM Quanfirmation™ capability makes the Q Exactive mass spectrometer the ideal solution for fast, easy residue screening and quantification in food safety, environmental and toxicology labs. The Q Exactive MS is superbly suited to routine bioanalytical quantitation of both large and small molecules; the superior quality of its HR/AM data supplying an added degree of confidence to these analyses. It is also ideal for pharmaceutical research laboratories looking for confident ID and precise quantification of metabolites, impurities, leachables and extractables. In short, the versatility and high data quality of the Q Exactive LC-MS/MS system make it a valuable addition to any modern laboratory.



    Identify, quantify and confirm with unmatched confidence using the Q Exactive mass spectrometer.

    • Resolving power up to 140,000
    • Maximum scan speed 12 Hz
    • Intra-scan dynamic range > 5000:1
    • Quadrupole mass filter
    • Spectral multiplexing for enhanced duty cycle
    • S-Lens ion source for increased sensitivity

    Mass Range

    m/z 50-6,000

    Max Resolving Power

    140,000 @ m/z 200

    Max Scan Rate

    Up to 12 Hz at resolution setting of 17,500 @ m/z 200

    Mass Accuracy

    Internal: < 1 ppm RMS External: < 3 ppm RMS under defined conditions


    Full MS: 500 fg Buspirone on column S/N 100:1 SIM: 50 fg Buspirone on column S/N 100:1

    Dynamic Range


    Polarity Switching

    One full cycle in < 1 sec (one full scan positive mode and one full scan negative mode at resolution setting of 35,000)


    Up to 10 precursors/scan

    Analog Inputs

    One (1) analog input (0 – 1 V) One (1) analog (0 – 10 V)


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